Designing a quality information site requires quality keyword research
It's impossible to ignore the importance of keyword research in the design stages of your website. A quality information site must cover the information that people want to read, and for that, you need to know what they type in at the search engines. The main pages of your website should offer information covering the main topics of your chosen niche. You can always add more articles to cover the less requested information later, and link to these from existing pages and the sitemap. It is standard practise to create a menu that appears on all pages of a site, with this menu linking to the main page. For that reason, you need to narrow your list of "main page" phrases down to 6 - 10. Too many phrases and your site starts to look spammy. Fortunately, deciding on which keywords encompass the entire niche is relatively easy if you have done your keyword research. Let's take an example. I went to Wordtracker and researched "blood pressure". My research found 140